Loutrochori is situated 30 kilometres (19 miles) north of the A2 motorway (Egnatia Odos, or A2, the Greek part of the E90) and 10 km (6 mi) south of the EO2 (or E 86).

The spa (iamatica loutra, ιαματικά λουτρά) of Loutrochori (spa-drinking therapy)[4] is situated just 0.5 km (0.3 mi) away near the local mountain of Canber (358 m or 1,175 ft).

It is 21 kilometres (13 miles) southeast of the regional unit capital of Edessa in Central part of Macedonia in Greece.

Loutrochori is bounded by the Imathia to the southwest and it is 28 kilometres (17 miles) northwest of the Imathian capital Veria.

It sits at an elevation of around 90 metres (295 feet) above mean sea level and the population is approximately from 500 (in winter) to 800 (in summer) inhabitants.