Pre-2020, the show would often open with an interview with a guest, often a Democratic politician, who doesn't join the panel discussion.

Occasionally though, guests such as House Intelligence Committee Chair Adam Schiff stay on and join the panel.

Panel guests have included comedians Sarah Silverman, Brett Gelman, Ira Madison III and Paul Scheer, screenwriter Wil Wheaton and journalists Lauren Duca, Ronan Farrow and Katie Nolan.

[10][4] The show was usually held in Los Angeles, California, at the Hollywood Improv, before moving to remote locations due to the COVID-19 pandemic.

Guests have included Kumail Nanjiani, Ike Barinholtz, Adam Conover, and Larry Wilmore.