The district includes the following municipalities: Dasher, Hahira, Lake Park, and Remerton, as well as the following census-designated places: Bemiss, Clyattville, Moody AFB, and Naylor.

[2] In 1957, voters in Lowndes County approved an $800,000 bond issue and the board got assistance from the State of Georgia for the construction of a new high school.

The new school was relocated to its present facility on Norman Drive near I-75 on the western side of Lowndes County.

[4] The facility built in 1966 has undergone multiple expansions to accommodate continued growth in student population.

[8][9] In January 2013, three-sport athlete Kendrick Johnson was found deceased at the school in a rolled up wrestling mat.

[10][11][12] On October 31, 2013, the U.S. attorney for the Middle District of Georgia announced he would open a formal review into Johnson's death.

[13] On June 20, 2016, the US Department of Justice announced that they would not be filing any criminal charges related to Johnson's death, stating "After extensive investigation into this tragic event, federal investigators determined that there is insufficient evidence to prove beyond a reasonable doubt that someone or some group of people willfully violated Kendrick Johnson's civil rights or committed any other prosecutable federal crime.

The video features the student being dragged across the floor of the cafeteria by a pride flag wrapped around their shoulders.

The perpetrating student was charged with disorderly conduct, simple battery, and disruption of a public facility.

[20] With the arrival of head coach Randy McPherson in 2002, the Lowndes High football program has undergone tremendous growth.

He previously served as a teacher, coach, and principal of Hahira High School for 10 years.

[27][28][29] The boys' golf team won the 2011 Class AAAAA state championship at Summit Chase Country Club in Snellville, Georgia.

In 2006 these musicians were invited to perform in Pasadena, California, for the "Tournament of Roses Executive Committee Luncheon" by Tournament President Libby Evans-Wright and for the 2006 parade grand marshal Supreme Court Justice Sandra Day O’Connor.