Low was of Dutch descent, and had emigrated with his wife and three small children from a rural village outside Amsterdam in 1778.

The village of Lowville was incorporated in 1854 and was designated the county seat in 1864, succeeding Martinsburg.

Daniel Kelley, along with his six sons, settled in Lowville in 1798, moving from Middletown, Connecticut.

In 1867, Datus' daughter Emeline (Kelley) Huntington wrote: "By a little brook which comes down from the long hills which rise almost like mountains on either side of the Black River, stands the same old mill where Father ground the wheat and corn for the country people.

"[citation needed] In 1810 Datus married Sara Dean and moved to Rockport, Ohio.

[citation needed] Agriculture and dairy farming flourished in the Lowville area because of the rich soil on the Black River Flats.

With the opening of the Black River Canal in 1851, the Rome, Watertown and Ogdensburg Railroad in 1867, and the Lowville and Beaver Railroad in 1906, industries flourished, including QubicaAMF (largest manufacturer of bowling pins in the world) and Kraft (the largest cream cheese plant in the country).

The site has 195 wind turbines, with a total capacity of 320MW (equivalent to a mid-sized power plant).

[citation needed] Peter Ostrum, who played the role of Charlie Bucket in Willy Wonka and the Chocolate Factory, lives in and practices veterinary medicine in Lowville.

Every year, there is a festival to celebrate the home of the World's Largest Cheesecake, made in Lowville, by Kraft.