[7] Analyses of DNA show that Loxocemus is most closely related to the true pythons and the sunbeam snakes.

It has been observed that both male and females have various scent glands on their bodies that secrete fatty acids and alcohols to deter nuisance arthropods, such as ants or other burrowing insects.

Scale coloring can also vary between pinkish-brown and reddish-brown, a source of camouflage depending on the soil type of the region an individual typically inhabits.

It is found along the Mexican Pacific versant at low to moderate elevations in the states of Nayarit, Jalisco, Colima, Michoacán, Morelos, Guerrero, Oaxaca, and Chiapas.

From there, its range extends south through Guatemala, Honduras, El Salvador, Nicaragua, and Costa Rica.