The term Loxodes derives from the ancient greek λοξός (loxós), meaning "oblique, tilted".

Both genera in the family Loxodidae have organelles known as Müller (or Müllerian) vesicles, which are involved in the sensing of gravity.

In Loxodes, the statolith is mostly composed of barium salts, compared to Remanella, where they are mostly strontium.

[4] Loxodes uses its Müller's vesicle to distinguish between up and down (geotaxis or gravitaxis), which it uses as a stimulus in addition to the oxygen concentration to orient itself in the water column.

[7] Loxodes uses a variant of the standard genetic code, where the stop codons UAA and UAG have been reassigned to the amino acid glutamine.