Loyalty and Betrayal is the sixth studio album by American rapper E-40.

Production was handled by Bosko, Rick Rock, Tone Capone, Blaqthoven, DJ Battlecat, DJ Silk, Don Juan, Jazze Pha, S.M.K.

Sean Pross and D-Wiz, with E-40 serving as executive producer.

It features guest appearances from The Click, Nate Dogg, 8Ball, Al Kapone, Birdman, Ice Cube, Jazze Pha, Kokane, Levitti, Mack 10, Mugzi, Mystikal, Otis & Shug, Pastor Troy, Pimp C and Too $hort.

WC made a cameo appearance in "Behind Gates" music video, while Ant Banks, JT the Bigga Figga, Mac Shawn and The Click were seen in "Nah, Nah..." music video.