It was released on November 9, 1999, on Sick Wid It and Jive Records.

The album was produced by D-Shot, Femi Ojetunde, Kevin Gardner, Mike Mosley, Redwine, Roger Troutman, Sam Bostic, Studio Ton and Tone Capone.

It features performances by Spice 1, Too Short, Kurupt, Daryl Hall, E-40, B-Legit, Celly Cel, Levitti, Bo–Roc, Roger Troutman and Mac Shawn.

Allmusic – "Sick Wid It...albums sold steadily throughout the...'90s, mainly because the label offered straight-up West Coast gangsta with no muss, fuss, or apologies.

Released in the waning months of the decade, Sick Wid It's Greatest Hits compiles the label's best-known singles and R&B/Rap chart hits, which mainly breaks down to three songs from E-40, three songs from Click, three songs from B-Legit, two from D-Shot, two from Celly Cel, and one from Suga T...it's not bad and certainly the cream of the Sick Wid It crop, which makes it a good choice for aficionados of the style or to anyone looking to dig a little deeper than Death Row and No Limit.