After completing high school at the Catholic "Collegio San Giuseppe", he worked as a bartender in a local nightclub while earning a degree in Economy & Commerce in 2004.

Argentero rose to fame in 2003 as a participant in the third season of the popular reality TV series Grande Fratello (Big Brother), arriving to the final and earning third place, with 9% of the Italian votes.

After this experience, Argentero began guest appearing on a variety of television shows and worked as a model, posing for a sensual calendar made by the Italian monthly magazine Max.

In 2005, Argentero made his debut as an actor in the television series Carabinieri, in which he portrayed the character of Marco Tosi in the fourth, fifth, and sixth seasons.

That same year, Argentero also made his cinematic debut in A Casa Nostra (Our Country), directed by Francesca Comencini.