[5] On 25 February 2023, Lipani made his professional debut, coming on as a substitute for Milan Badelj at the 85th minute of a Serie B match against SPAL: in the same occasion, he served an assist for Eddie Salcedo, whose goal settled up the game's final score for a 3–0 win.

[8][9] On 8 August 2023, Lipani joined fellow Serie A club Sassuolo on a permanent deal,[10][11] for a reported fee of eight million euros, plus add-ons.

[3][12] On 2 November, he made his debut for the club, coming on for Uroš Račić in the first half of extra-time of a Coppa Italia match against Spezia,[13][14] which ended in a 5–4 win on penalties.

[17][18] In May 2022, he was included in the Italian squad that took part in the UEFA European Under-17 Championship in Israel:[21] during the tournament, he scored a goal,[18] as the Azzurrini were eventually eliminated by the Netherlands (2–1) in the quarter-finals.

[2][22] In May 2023, he was included by head coach Carmine Nunziata in the Italian squad that took part in the FIFA U-20 World Cup in Argentina,[20] where the Azzurrini finished runners-up after losing to Uruguay in the final match.