With the U20 national team, he won the bronze medal at the European Championships in Celje, Slovenia in the summer of 2018.

[3] In October 2019, Witzke was nominated for a training and international match week for the senior national team.

On 5 November 2021, Witzke made his debut for the senior national team in a friendly against Portugal in Luxembourg.

At the 2022 European Championship, he played two games before a positive COVID-19 test ended his tournament.

[5] At the 2023 World Cup, he reached 5th place with the German national team, and Witzke scored 20 goals.