His publishing business was successful, and among the most important in the late fifteenth and early sixteenth centuries.

At about the time of his death in 1538 there were Giunti presses in Florence and Lyon, Giunti bookshops or warehouses in Antwerp, Burgos, Frankfurt, Lisbon, Medina del Campo, Paris, Salamanca and Zaragoza,[1] and agencies in numerous cities of the Italian peninsula, including Bologna, Brescia, Genoa, Livorno, Lucca, Naples, Piacenza, Pisa, Rome, Siena and Turin, as well as the islands of Sardinia and Sicily.

[1][4]: 337  In 1489 he started book publishing with three titles: the works of Ovid; an anonymous translation into the volgare of the Transito de sancto Hieronymo, partly by Eusebius Cremonensis; and a translation of the Imitatio Christi, authorship of which he attributed to Jean Gerson.

[1] From 1491 Giunti was constantly active as a publisher, and later as a printer too; he issued some 410 titles during his lifetime.

He did not have his own printing workshop until about 1500; until that time, he employed independent typographers, most frequently Johan Emerich of Speier.