Lucerne is a village in western Putnam County, Missouri, United States.

[7] Lucerne is located on US Route 136 approximately 15 miles west of Unionville.

Medicine Creek flows past one-half mile to the east.

[8] The Chicago, Milwaukee, St. Paul and Pacific Railroad passes the east side of the location.

[9] According to the United States Census Bureau, the village has a total area of 0.25 square miles (0.65 km2), all land.

The racial makeup of the village was 95.65% White, 2.17% African American, and 2.17% from two or more races.

There were 28.0% of families and 41.2% of the population living below the poverty line, including no under eighteens and 27.6% of those over 64.