Worthington is a village in southeast Putnam County, Missouri, United States.

[6] Worthington is located on Missouri Route W approximately one-half mile west of the Putnam-Schuyler county line which is on the Chariton River.

[7] According to the United States Census Bureau, the village has a total area of 0.11 square miles (0.28 km2), all land.

39.4% of all households were made up of individuals, and 3% had someone living alone who was 65 years of age or older.

28.6% of all households were made up of individuals, and 7.1% had someone living alone who was 65 years of age or older.

There were 52.0% of families and 42.1% of the population living below the poverty line, including 60.0% of under eighteens and 14.3% of those over 64.