[1] In 2017, with the end of the Renzi government, Lamorgese became prefect in Milan, replacing Alessandro Maragoni in the post.

On 13 November 2018 she was appointed as a state councillor by the Council of Ministers chaired by Giuseppe Conte, who was forming his first government.

[1] In September 2019, with the collapse of Conte's and M5S's government alliance with Matteo Salvini, a new coalition was formed between the M5S and the centre-left Democratic Party and Free and Equal.

[5] Shortly after taking office in September 2019, Lamorgese agreed with her counterparts from France, Germany, Malta, and Finland, which held the rotating presidency of the Council of the European Union at the time, on redistributing migrants on aid ships to some EU member states immediately following their rescue.

[6] Under Lamorgese's leadership, the government approved a 2021 bill to tackle gender-based violence and strengthen surveillance on suspects, authorizing police to take action against suspects even if the victim herself does not report the offence – a move aimed at helping women who are afraid of filing formal accusations.