After obtaining a degree in law,[1] Carfagna worked for several years on Italian television shows and as a model.

From 2000 to 2006 she participated as a showgirl in the television program La domenica del villaggio ("Sunday in the Village") with Davide Mengacci.

[11] When she first entered parliament Berlusconi jokingly commented that Forza Italia practiced the law of primae noctis; the right of a feudal lord to take the virginity of his female subjects.

In the same year she signed a campaign against homophobia in Italy, with television spots, images on magazines and wall attachments on cities.

It approved funding for childcare facilities and in support of motherhood and family that made it possible to increase by a few percentage points the availability of places for working mothers.

[26] In August 2019, the Codice Rosso ("Red Code") legislation, proposed by Carfagna, enters into force in Italy to combat violence against women with more efficient investigations and more severe penalties.

[31] In May 2010, during the Quirinal Palace ceremony on the occasion of International Day Against Homophobia, Transphobia and Biphobia, Carfagna publicly apologized for the statements she made two years earlier, saying "she was helped in breaking through the wall of mistrust of which she was at the same time victim and unconscious responsible".

[35] In November 2008 Italian journalist Paolo Guzzanti wrote on his blog about Carfagna, saying: "Is it admissible or ineligible, in a hypothetical democracy, that the head of a government nominate a minister who has the one and only merit of having him personally served, excited and satisfied?

",[36] thus highlighting the words spoken by his daughter Sabina Guzzanti at "No Cav Day" anti-Berlusconi protest movement in July 2008.

[37] Carfagna sued la Repubblica for having reported Sabina Guzzanti's words that alluded to her sexual activity with Berlusconi.

[39][40] On 25 June 2020, Carfagna, as vice president of the Chamber of Deputies, ordered the forced expulsion of Vittorio Sgarbi who, pronouncing himself on the decree amending the law containing urgent measures concerning criminally relevant wiretapping, pronounced the following: "If a criminal commits a crime is normal, but if a Judge does it, it's an institutional earthquake.

After the declarations without precedents against you coming from a Judge of Superior Council, after the unprecedented statements of Palamara against Mr. Salvini, we must open a commission of inquiry against the crime of magistrates who do the opposite of their work, worse than criminals".