In addition to her medical and literary efforts, Gamero was an active feminist and suffragette, attending conferences and participating in the founding of the Comité Femenino Hondureño.

[1] In 1924, she was appointed to head the Hospital de Sangre in Danlí and from 1930 served as the health inspector of the El Paraíso Department.

[2] She began writing as a child,[5] publishing in the magazine La Juventud Hondureña (Honduran Youth) from as early as 1891.

[1] Gamero authored the first novel ever published by a Honduran woman, Amalia Montiel,[4] which was released in 1892,[1] as serialized chapters in the weekly newspaper El Pensamiento, directed by Froylan Turcios.

[6] Gamero de Medina's novels are a staple of the literature curriculum in high schools and universities in Honduras and she is considered one of the most important literary figures of Central America in the late nineteenth century.

[4] Gamero was a member of numerous literary associations of Central America, the Honduran Academy of Language, and wrote her autobiography in 1949.