Lucille Has Messed My Mind Up is the debut album of American musician Jeff Simmons.

The album features musicians Craig Tarwater and John Kehlior, both of whom had previously been members of the Seattle group The Daily Flash.

Lucille Has Messed My Mind Up was described as the second best album on the Straight Records label by Mojo Magazine.

[citation needed] In 2007, it was re-issued on CD by World In Sound Records.

Another track, "Wonderful Wino", was rerecorded and released on Zappa's 1976 album, Zoot Allures.