Not long after he got his license, he took his savings earned thanks to his summer jobs and, with the help of his father Luciano, he bought a Honda NS125 starting his dream to become a professional racer.

When he turned eighteen, he got the approval of his father to begin racing, and in 1989, made his debut as rider in the Italian Sports Production Championship riding a Honda 125 NSR.

Two years later, he earned his European Runner-up award in the 125 cc class, and in 1993, he made his debut in the World Championship.

The following year, the GIVI team offered Cecchinello the opportunity to race in the MotoGP, riding a Honda RS 125cc, during which he scored his first points in a World Championship.

Lucio had his first victory at the 125cc World Championship at Jarama race track in Spain in 1998: During the same season, his teammate was Japanese rider Noboru Ueda.

Before ending his racing career Cecchinello realized one of his dreams taking the victory at the 2003 Italian Grand Prix at Mugello.

In 2002, the team ran extra bikes in 250cc, giving future MotoGP champion Casey Stoner his first full-time ride in the 250cc championship.

Cecchinello retired after the 2003 season, but the team continues in the championship with Casey Stoner, and Randy de Puniet as the main rider.

In the process, Crutchlow achieved LCR's first podium since Stefan Bradl finished second at the 2013 United States Grand Prix.

Crutchlow crashed at out at the season opener in Qatar, but rallied at the second race in Argentina to take a podium in 3rd place.

In 2021, Alex Marquez jumped into the team as Nakagami's teammate, after Cal Crutchlow's decision of retirement at the end of 2020.