The station is located at kilometre 76.0 (measured from Berlin) of the Berlin–Dresden railway to the west of the centre of Uckro, a hamlet that is in the territory of the town of Luckau in the Brandenburg district of Dahme-Spreewald.

The original plans of the Berlin-Dresden railway had provided for a route through the town of Dahme, but this failed because of the resistance of the local mayor.

After the town of Luckau decided not to take part, the Dahme-Uckroer-Eisenbahn AG (Dahme-Uckro Railway, DUE) was founded on 21 October 1884.The 12.6 km long section from Uckro to Dahme went into operation on 31 July 1886.

[5] In the 1890s planning began on the building of a railway line from Falkenberg via Uckro, Luckau to Lübben.

The Lower Lusatian Railway (Niederlausitzer Eisenbahn, NLE) went into operation between Luckau and Uckro on 20 December 1897.

In October 1953, Uckro station was the starting point of one of the largest pursuit ever carried out by East Germany's Volkspolizei (“People's Police”), when five young men from Czechoslovakia, the Mašín brothers and three of their friends, who are still referred to as either anti-Communist martyrs or as criminals, came here as they attempted to reach West Berlin.

As a result, two police commissioners were killed whilst one fugitive seceded from the group and was subsequently apprehended.

With the beginning of the division of Berlin and Germany in the late 1940s, the importance of Uckro station grew.

Freight traffic had fallen significantly, there were no longer military reasons for bypass routes and there was growing competition from cars in passenger transport.

The section between Uckro and Luckau was abandoned in February 1995 because of the poor condition of the track and it no longer used by regular passenger services.

This involved the building of a new bus station, 55 parking bays and a covered bicycle facility at a cost of €580,000.

[11] The complex also includes a "residential house for railway staff with a stable building" to the south of the station forecourt.

The track layouts of the two private railways were relatively less extensive, since the centres of operations of both companies was not in Uckro but in Dahme and Luckau.