Accompanied by his faithful horse Jolly Jumper and almost every episode by Rantanplan the prison guard dog (who gets lost in the West by wanting to follow Lucky Luke or find his prison), he finds himself confronted with various bandits and thugs like the Dalton Brothers, Billy the Kid, Jesse James, and Phil Defer.

[7] During the series' production and appearance on the American television, Lucky Luke must comply with a few rules to avoid falling foul of the censorship of children's programs.

First, Lucky Luke's cigarette was replaced by a blade of grass, a change that would later also occur in the comic series.

[8] Another big change is that ethnic minorities are disappearing: no more Chinese launderers, no more black servants, no more “redskin”-speaking Amerindians.

This adaptation will also give the animals Jolly Jumper and Rantanplan a much more important place than in the comics.

Episodes never had the same design, which was explained by the services of several subcontracted animation studios (in the United States, Spain and Australia).