Lucrezia Donati (Florence, Italy; 1447-ibidem, 1501) was an Italian noblewoman, mistress of Lorenzo de' Medici.

[1] The identity of the woman in the sculpture Dama col mazzolino, at Bargello Museum in Florence could be attributed to Lucrezia Donati.

[7][8] Lucrezia was the daughter of Manno Donati and Caterina Bardi, a Florentine dame[9] who belonged to an extinct family tree, being the last descendant.

Lucrezia married the Florentian businessman Niccolò Ardighelli, who died in exile in 1496.

[9] The actress Laura Haddock starred as Lucrezia Donati in the television series Da Vinci's Demons.