Lucrezia d'Alagno (c. 1430 – September 23, 1479) was a noblewoman with whom King Alphonso V of Naples had fallen in love.

In 1461[dubious – discuss], Lucrezia acquired, for example, the Castello del Caiazzo for fifteen thousand ducats through the intercession of Alfonso.

Lucrezia in turn entrusted the island's governance to her brother-in-law, Giovanni Torella.

The king also asked for an annulment to his marriage with Maria of Castile, but Pope Callistus III refused it.

Lucrezia nevertheless served as de facto queen at the Neapolitan court as well as an inspiring patron to the circle of scholars and poets who surrounded Alfonso, including Antonio Beccadelli and Giovanni Pontano.