Durack has played the roles of Peggy Sawyer in 42nd Street,[2] Miss Dorothy in the Australian Premiere of Thoroughly Modern Millie,[3] Lois Lane/Bianca in Kiss Me, Kate,[4] Rikki Rose in Respect,[5] Sybil Chase in Noël Coward's Private Lives,[6] and Laurey in Oklahoma!.

[7] Durack's screen credits include the role of Cherry in the feature Goddess, Bunny in Southern Star/UKTV telemovie Dripping in Chocolate, Cassie Bennett on Channel Seven's headLand, All Saints, Rush II, Spicks and Specks, Parlami d'Amore,[8] the Australian feature film Finding Nigel and the worldwide broadcast of the BBC2 Voice of Musical Theatre Competition in Cardiff[9] in which she was a finalist.

Durack sang the National Anthem at the AFL Grand Final[12] and at Oaks Day as part of Melbourne's Spring Racing Carnival and performing on Channel 9's Carols By Candlelight and Channel Seven's Carols in the Domain, all as part of the cast of Wicked.

[14] In March 2012, it was announced that Durack would play the main character, Elle Woods in the Australian production of Legally Blonde,[15] which also feature her Wicked co-stars Rob Mills and David Harris as Warner Huntington III and Emmett Forrest respectively.

[19] In 2019, Durack was announced as one of the new judges for the ninth season of Australia’s Got Talent alongside Shane Jacobson, Manu Feildel and Nicole Scherzinger and new host Ricki-Lee.

In January 2020, Durack portrayed Princess Fiona in the Australian production of Shrek The Musical in Sydney before transferring to Melbourne.

[23][24] Durack married Christopher Horsey on Rottnest Island off the coast of Perth, Western Australia on 5 April 2014.