Lucy Hughes Brown was born an orphan[4] in Mebane, North Carolina, on April 12, 1863 .
[10] Hughes Brown was the first African American woman licensed to practice medicine in North Carolina.
[2] Brown practiced medicine in Wilmington, North Carolina for two years, and then in 1896 she and her husband moved to Charleston, SC.
[11] She joined with other black professionals—including Dr. Alonzo Clifton McClennan—to cofound the Canon Hospital and Training School for Nurses in 1897.
[5][6] Brown also was associate editor of the state's first black medical periodical, the Hospital Herald, which was founded in 1898.