Giuly represented France at international level, gaining 17 caps over a five-year period and was a member of their 2003 FIFA Confederations Cup-winning squad.

Ludovic Giuly made his debut in the club in which his father was then active: the ASCMO, now known as Monts d'Or Azergues Foot, in the city of Chasselay, located about twenty kilometers from Lyon.

[citation needed] Giuly began his career with Lyon in 1994 at age 18, and made his debut for the club in a Division 1 match on 21 January 1995 against Cannes; a 3–1 win.

[citation needed] Just ten days after playing for Lyon against Marseille, Giuly made his Monaco debut against them in a 1–1 draw on 20 January 1998.

[citation needed] In the 1999–2000 season, Giuly proved to be a key member in the Monaco squad on its right side, as he led his team to the Ligue 1 title for the first time since 1997.

[citation needed] At the start of the 2003–04 season – Giuly's last with Monaco – he scored a superb overhead kick during a league match against Lens with an assist from Jérôme Rothen, having suffered an injury that kept him out for a week prior to the game.

[5] This was a particularly galling defeat for Giuly because he suffered a groin injury early in the match, forcing him to leave the field in the 23rd minute, being replaced by Dado Pršo.

Although his season was disrupted by several muscle injuries, Giuly was able to fulfil his promise to reach double digits in goals in his first year at his new club.

[citation needed] In 2005–06, he helped win the Spanish title again, as well as capture the second UEFA Champions League trophy for the Catalan club.

[10] Giuly subsequently scored, but the goal was ruled out due to the foul resulting Jens Lehmann sending off (making him the first player and only goalkeeper to ever be sent off in a Champions League/European Cup final).

[11] In the 2006–07 season, Giuly, although still a key member of the Barça squad, eventually lost his starting spot in the team, when Lionel Messi was promoted from the club's youth ranks.

[12] On 17 July 2007, Giuly signed for Roma on a three-year deal after the club paid a £2.2 million transfer fee to Barça.

In the UEFA Champions League group stage, Giuly scored and provided assist for Mirko Vučinić in a 4–1 win over Ukrainian side Dynamo Kyiv on 27 November.

In the second leg of the round of 16 in the Coppa Italia, he also scored and provided two assists for Mancini and Roma fan favourite Francesco Totti in a 4–0 win over Torino on 16 January 2008.

[14] Desiring to return to France for more playing time, Giuly was coveted by Monaco, Marseille and Lyon, but on 18 July 2008, he signed with Paris Saint-Germain on a three-year contract, with PSG paying a reported €2.5 million transfer fee to Roma.

In his first season at the club, PSG had moderate success in Ligue 1, finishing in sixth place and narrowly missing out on European play due to inferior goal difference.

[16] In his third and final season (2010–11), Giuly began by scoring in play-off round of the UEFA Europa League, away at Maccabi Tel Aviv.

[citation needed] Ahead of the 2012–13 season, Giuly found himself being frozen out of the first team by newly appointed manager Claudio Ranieri and lost the captaincy to Andreas Wolf.

[26] Giuly has been capped for France, but was removed from his country's UEFA Euro 2004 squad due to a leg injury he sustained in the 2004 Champions League final.

[30] From September 2006 to March 2007, Giuly worked as a columnist each Thursday in Luis Attaque on Radio Monte Carlo (RMC).

[citation needed] Giuly tested positive for the H1N1 (Swine flu) virus in October 2009 along with two PSG teammates, Jérémy Clément and Mamadou Sakho.