Beginning in 1634 with Niccolò I Ludovisi, one branch of the family ruled the Principality of Piombino.

Alberico Boncompagni Ludovisi, prince of Venosa, was a winemaker at his estate Fiorano from the late 1940s to 1995.

Bertrando then inherited the surname and the coat of arms of the Ludovisi, and, through his descendants, began a new dynasty.

His son, Girolamo Ludovisi, was a senator and gonfalonier of Bologna, only to be deposed by the Bentivoglio family in 1511 and murdered.

Girolamo's son, Niccolò Ludovisi, was count of Samoggia and Tiola and again a senator.