Ludvig M. Sollid (born September 18, 1962) is a Norwegian physician-scientist whose laboratory has made discoveries in the pathogenesis of HLA associated human disorders, most notably celiac disease.
He and his coworkers demonstrated that celiac disease patients who express HLA-DQ2.5 have gluten-specific CD4+ T cells in their gut mucosa that recognize gluten antigen in the context of this HLA molecule.
[4] Later he showed that celiac disease patients who express HLA-DQ8 and HLA-DQ2.2 have gluten-specific T cells that recognize gluten antigen in context of these HLA-DQ molecules.
[8] The research group of Sollid identified the sequence of immunodominant gluten peptides recognized by T cells of celiac disease patients.
This work has allowed detailed analysis of how celiac antibodies recognize the autoantigen, and it has enabled the establishment of a mouse model to study autoantibody formation to transglutaminase 2.
[14] Collectively, his work gives mechanistic insights into how the disease-predisposing HLA-DQ molecules, via presentation of posttranslationally modified gluten peptides, are connected to the generation of autoantibodies to transglutaminase 2 in celiac disease, as reviewed.