Later, even though he had not yet made a final decision to be an artist, he studied with Henry Fuseli (one of his father's customers) and Hans Jakob Oeri.
That year he, Pforr, Overbeck and Konrad Hottinger (1788-1828) decided to make a journey to Rome, where he became part of a group that included Bertel Thorvaldsen, Joseph Anton Koch and Peter von Cornelius, and came under the influence of the Quattrocentists.
Once there, he established a studio in a home his father had acquired in Upper Schönenberg that had formerly belonged to Johann Jakob Bodmer.
He then produced a series of paintings portraying the folk life and history of Switzerland; an activity he continued into the 1860s.
He later became the patron of the Swiss history painter, Johann Caspar Bosshardt who, with his assistance, was able to enroll at the Kunstakademie Düsseldorf and study with Theodor Hildebrandt.