Luigi Fontana (born April 22, 1969) is a physician scientist who studies healthy longevity, with a focus on calorie restriction, endurance exercise and metabolism.

Around 2012 he started a long-term study of 45 members of the Calorie Restriction Society and age-matched endurance athletes with the intention of tracking their health for around 12 years each.

[7][8] He also has been a primary investigator in the CALERIE trial, which started in 2007, in which people were placed on a diet with 25% fewer calories and received regular counseling to help them remain on it.

[10] This approach is based on evidence from the "biology of ageing" field showing that targeting well-characterized metabolic and molecular pathways can inhibit the accumulation of cellular and tissue damage, and extend healthspan and influence the clinical progression of multiple chronic conditions.

In 2013, he wrote a perspective article with Daniel Kammen on the beneficial role of efficient use of energy and food in promoting human, environmental, and planetary health, and sustainable economic development.