He was ordained a priest at the Pontifical Roman Major Seminary on 30 November 1974 by Cardinal Ugo Poletti.

[1][2] He then received a bachelor's degree in philosophy from the Pontifical Lateran University and a licentiate in moral theology from the Alphonsian Academy.

[1][2] He was consecrated a bishop in the Papal Archbasilica of St. John Lateran on 12 September 1998 by Cardinal Camillo Ruini.

[2] From 17 October 2003, he held the position of Vicegerent of Rome and in 2004, he assumed the role of auxiliary bishop for the eastern sector of the diocese.

[2] Moretti also held the position of ecclesiastical assistant to Pius Sodalizio dei Piceni, was a member of the committee for the foundation of religion and worship of called Istituto Guido and Bice Schillaci Ventura, was on the council for economic affairs of the Diocese of Rome, was the episcopal president of the family and life commission of the Lazio Episcopal Conference, was a member of the family and life commission of the Italian Episcopal Conference, and was the national ecclesiastical assistant to UNITALSI.