After a two-year stint with Standard Liège, he signed a contract with French Ligue 2 club AC Arles-Avignon on 19 July 2011.
His playing career came to a halt in the end of the 2012–13 season when he retired at the age of 32 due to a long time Phlebitis.
[1][2] Pieroni left Standard in the summer 2019, to become the assistant manager of his former teammate, Christophe Grégoire, at Royal Football Club Seraing.
[3] After promotion to the Jupiler Pro League in 2021, Luigi Pieroni left Seraing to train the U16 youth of KAA Gent, following head coach Emilio Ferrera who became head of youth at Gent.
On 16 November 2021, it was reported that Pieroni had quit the U16 of Gent to become the assistant of Marc Wilmots at Raja CA.