Luigi Ruffo-Scilla JUD (25 August 1750 – 17 November 1832) was a Cardinal of the Holy Roman Church who served as Apostolic Nuncio to Austria and Archbishop of Naples.

He was educated at La Sapienza University, Rome, where he earned a doctorate in utroque iure (i.e., in both canon and civil law) on 3 December 1772.

He was served as Nuncio in the Grand Duchy of Tuscany from 26 April 1785 until 1793.

He was created and proclaimed Cardinal-Priest of San Martino ai Monti in the consistory of 23 February 1801.

He was later reunited with Pope Pius VII and other cardinals in the castle of Savona.