Luigi Sepe (born 8 May 1991) is an Italian professional footballer who plays as a goalkeeper for Serie B club Salernitana.

Born in Torre del Greco, the Province of Naples, Sepe made his debut for his hometown club in Serie A on 28 January 2009, aged 17, during the match against Fiorentina, lost 2–1.

In 2010–11 season, he was named in 2010–11 UEFA Europa League as list B member (U21 youth product), which he was the fourth keeper behind Morgan De Sanctis, Iezzo and Gianello.

[5] Sepe started three out of four matches for the Italy U18 team at the U18 Slovakia International Cup, ahead if Valerio Frasca in April 2009.

In 2011, Sepe married Anna Laura Acampora, the niece of former footballer and now coach Carmine Gautieri.