Luigi Sepiacci

(12 September 1835 – 26 April 1893) – born Domenico Daniele Sepiacci – was an Italian prelate of the Catholic Church who held senior positions in the Roman Curia from 1886 until his death.

Domenico Daniele Sepiacci was born in Castiglione del Lago, Italy, on 12 September 1835.

He was ordained a priest on 29 May 1858 by the Cardinal Archbishop of Perugia Gioacchino Vincenzo Pecci, who later became Pope Leo XIII.

He earned degrees in philosophy, theology, and Oriental languages, and he taught in Belgium and Italy.

He received his episcopal consecration on 18 March from Raffaele Monaco La Valletta, Cardinal Vicar of Rome.