Luino (Western Lombard: Lüin) is a small town and comune near the border with Switzerland on the eastern shore of Lake Maggiore, in the province of Varese, in the Italian region of Lombardy.

In the Middle Ages it was contested between powerful families from Como and Milan, but was able to maintain its status as a free commune.

As part of the Duchy of Milan, it was acquired by Spain in the early 16th century and, in 1541, king Charles V gave it right to hold a market in alternance with Maccagno, who had been enjoying it alone so far.

The area of Luino underwent a high industrialization process, starting from the late 19th century, which caused significant ecological damage to the eponymous Lake.

Two notable figures of 20th century Italian literature, Piero Chiara and Vittorio Sereni, were born in Luino.