Luis Antonio Colón Aquino [ah-KEE-noh] (born May 19, 1964) is a Puerto Rican former middle relief pitcher in Major League Baseball who played for the Toronto Blue Jays (1986), Kansas City Royals (1988–1992), Florida Marlins (1993–1994), Montreal Expos (1995) and San Francisco Giants (1995).

He was later traded to the Kansas City Royals for Juan Beníquez.

Aquino played most of his professional career with the Royals, but also had major league appearances for the Marlins, Expos and Giants.

Aquino was a member of the inaugural Florida Marlins team that began play in 1993.

This biographical article relating to a Puerto Rican baseball pitcher is a stub.