Karros was born in Hackensack, New Jersey, and graduated from Patrick Henry High School in San Diego, California.

[2] The Los Angeles Dodgers selected Karros in the sixth round of the 1988 Major League Baseball draft.

Karros recorded his first Major League hit as a pinch hitter in the bottom of the 12th inning against Cincinnati Reds pitcher Milt Hill on September 16, 1991.

[citation needed] In his first at-bat of the 1992 season, on April 9 against the San Diego Padres, Karros hit a two-run shot to deep left field off of Craig Lefferts for his first career home run.

He became the third Dodgers player in history to record 30 home runs and 100 RBIs in five different seasons (alongside Duke Snider and Gil Hodges).

[citation needed] On December 2, 2002, the Dodgers traded Karros and Mark Grudzielanek to the Chicago Cubs in exchange for Todd Hundley and Chad Hermansen.

He previously worked for Fox Sports in 2004 doing the pregame shows for the Major League Baseball playoffs, and ESPN until 2006 as a studio and game analyst.