Luis Fernández de Córdoba (born c. 1480, died 17 August 1526) was a Spanish nobleman, count of Cabra and viscount of Iznájar, lord of the house of Baena, Duke of Sessa, of Terranova and of Santángelo by his marriage to his cousin, Elvira Fernández de Córdoba y Manrique (all of these duchies were created, between 1497 and 1507, for Elvira's father, the "Great Captain" Gonzalo Fernández de Córdoba).
He was in Italy in mid-1521, in the Sixth Italian War, as one of the candidates for the general captaincy of the Spanish army (the position was given to Fernando d'Ávalos in 1522).
In 1526, at the start of the Seventh Italian War (the War of the League of Cognac), where the emperor and the pope found themselves on opposing sides, he marched to the Kingdom of Naples together with Hugo of Moncada to gather troops against Rome (ultimately resulting in the Sack of Rome on 6 May 1527).
He fell ill in San Marino, and asked Clement VII for permission to enter the city of Rome to be treated.
The firstborn, Gonzalo II Fernández de Córdoba (1520–1578), inherited his titles.