Duke of Sessa is a Spanish noble title awarded to Gonzalo Fernández de Córdoba by Ferdinand II in 1507.

Its territorial designation refers to Sessa Aurunca, at the time in the Kingdom of Naples.

The title is one of the numerous duchies created by the Catholic Monarchs and never represented any territorial claim.

With the loss of the Kingdom of Naples in 1806, the designation has ceased to be located in Spanish-controlled territory.

The surname of Fernández de Córdoba was retained by the 3rd duke and his sister, the 4th duchess, due being the offspring of a cousin marriage.