Ortega attended film school at the Universidad del Cine in Buenos Aires.

He wrote the screenplay for his feature film Black Box when he was 19 years old.

Diana Sanchez said, "With only two feature films ... Luis Ortega is already considered one of Argentina's more impressive and original directorial voices.

His first feature, Black Box, stood apart from the social critiques that characterized the films of his Argentine contemporaries.

In 2016, he directed the successful television series El marginal, that was released in October 2016 by Netflix and in January 2018 by Universal Channel.