His father, a shoe cobbler, died in 1899, and young Luis Perlotti was compelled to find work.

[1] He became acquainted with other Argentine artists, including painter Benito Quinquela Martín, poet Alfonsina Storni, and others, who would gather at the Café Tortoni.

[1] He would be commissioned to create large-scale works for both public display and for private clients, notably the Mar del Plata monument to his friend, the poet Alfonsina Storni, which would be placed in 1942 opposite the place where she had committed suicide; Perlotti engraved her 1925 poem, Pain, upon the memorial.

Other notable works would include the Monument to Bartolomé Mitre, in the city of Corrientes; the monument to Los Libres del Sur, in the city of Chascomús; Return to the Fatherland, in Tunuyán, Mendoza; The Dance of the Arrow, in Paraná, Entre Ríos (which had earned a gold medal in the Ibero-American Exposition of 1929, in Seville); the monument to the Andes, Los Andes Park, in the Chacarita ward of Buenos Aires; La Piedad, in Chacarita Cemetery; memorials to Generals Juan Lavalle and Pablo Riccheri, and boxer Luis Firpo, in La Recoleta Cemetery; a monument to motherhood, in Rivadavia Square; relief in homage to Lady Liberty on the base of the Plaza Arenales flag pole; a monument to José de San Martín, located in the Supreme Court; and the Martín Fierro Award, among numerous other works.

Vacationing in Punta del Este, Uruguay, in January 1969, the noted sculptor died in an automobile accident.