Luis de Ayala y Vergara (February 19, 1768 – April 26, 1839) was a criollo lawyer, politician from the capital of the Viceroyalty of the New Granada.

[3] On his father's side, they were members of an honorable family descended from secretaries of the Royal Archive of Simancas, a title granted by Felipe II and carried by several generations.

Maria Josefa de Vergara Azcárate y Caycedo is descendant of Navarrese nobility and important houses of the Basque Country, more specifically from the town of Bergara in the province of Gipuzkoa, Spain.

Luis was brother of one of the main officers who had risen up against Nariño, José de Ayala y Vergara who was shot in public display in 1816 by the Spanish Empire, for his love and services to the new Republic, the same year of 1816.

in 1801 joined the Sociedad Patriotica or Patriotic society; a group of the wealthiest families of the new kingdom created to promote the wellbeing of its citizens, from here Luis started participating in the Independence efforts.