[1] He was ordained a priest in the Order of Saint Jerome where he served as the prior of the convent of Mejorada del Campo.
[1][3] In April 1516, he was elected as the commissioner of the Indies and tasked by cardinal Francisco Jiménez de Cisneros, regent of Spain, with stopping the abuses committed by the encomenderos as urgently documented by father Bartolomé de las Casas.
[1] Adviser to the King and treasurer of Spain, Miguel de Pasamonte proposed Figueroa for bishop of the Diocese of Santo Domingo and President of Santo Domingo, which would have made him the highest religious and political dignitary in the Indies.
[1] The request was officially granted by Pope Clement VII in 1524 although Luis de Figueroa had already died on March 23, 1523, at the convent of Mejorada.
[1] Sebastián Ramírez de Fuenleal was appointed bishop of Santo Domingo in his place.