Luisa Guidotti Mistrali (16 May 1932 – 6 July 1979) was an Italian laywoman of the Roman Catholic Church who worked in the missions in Rhodesia.

[1] Guidotti tended to the ill in several hospitals across Rhodesia and was even noted for taking care of Robert Mugabe's mother on one occasion.

[1] Guidotti returned to her homeland in July 1967 and on 12 September at the Benedictine Metten Abbey in Germany became part of the Association in full.

On 24 June 1976 a guerilla named Antony Nodo was injured during fierce fighting and came to the hospital in need of urgent medical attention.

Guidotti arranged for both a diagnosis and treatment for Nodo but was arrested for this on 28 June after the government alleged that she was aiding and abetting guerilla forces.

When they observed a vehicle approaching which turned off before the roadblock, it was assumed to be absconding and a number of shots were fired, one of which struck Guidotti, who was rushed to the Mtoko Hospital, but succumbed.

The Archbishop of Harare Patrick Fani Chakaipa celebrated her funeral Mass on 12 July though her remains were later relocated to the Modena Cathedral on 23 October 1988.

The official commencement for the cause came under Pope John Paul II on 21 April 1995 after she had been titled as a Servant of God and the Congregation for the Causes of Saints declared the nihil obstat to the cause meaning there were no objections for its initiation.