She is married to Prince Lorenz of Belgium, head of the Austria-Este branch of the House of Habsburg-Lorraine, and is fifth in line of succession to the Belgian throne.

All male-line members of the family are entitled to the title Prince/ss de Croÿ in the Kingdom of Belgium with the style of Serene Highness, while the Head is also the Duke.

After working closely with editor in chief Edward Enninful, she was promoted to Global Network Lead & European Features Director in 2020, a position she held for three years.

On May 2023, she joined Anna Wintour's executive team in American Vogue as Global Head of Fashion Network, a role previously held by Virginia Smith.

She declined to stand again for election to the role in light of internal struggles in the organisation in reconciling its Flemish-speaking and French branches, each of which seeks greater autonomy.

[12] Princess Astrid has been for many years an advocate for landmine survivors rights, participating actively in the work of the Anti-Personnel Mine Ban Convention, also known as the Ottawa Treaty, since Belgium joined in 1998.