In 1999, while exercising as housekeeper,[1] she began in politics, being the head of the People's Party list in the 1999 municipal elections of San Vicente del Raspeig, after which she failed to achieve the mayoralty to be left behind the PSOE.

The tripartite governed by the socialist Canals was maintained for a year and a half until 10 October 2001, when through a motion of no-confidence, Luisa Pastor became the first mayoress of San Vicente del Raspeig with the votes of the PP, Jaime Antón of the PSVI and the four councilors José Gadea, Elena Moltó, Celia Sáez and Mercedes Medina, who were defectors since May when they had resigned from the PSOE.

[2] In the 2003 Spanish local elections, Luisa Pastor obtained an absolute majority for the first time for her party in San Vicente, taking 11 of the 21 council members of the Plenary.

The duo worked with her husband José Ramón García Antón, who from the Generalitat Valenciana, brought many investments to San Vicente del Raspeig.

In October 2009, it was speculated that she would opt for Secretary-General of the People's Party in the Valencian Community after the vacancy left by Ricardo Costa Climent.