Though she felt an interest in natural sciences from an early age, at 17 she began publishing in several newspapers, such as Atlántida, El Hogar and Esto Es, and worked for Radio Belgrano, as well.
At 20, just barely married to Theodore Marjak, a French merchant marine, she moved to Paris where she worked for Radio Télévision Française, and met members of both the nouveau roman literary movement and Tel Quel.
As a consequence of the National Reorganization Process, that partially censored her novel He Who Searches (Como en la guerra) by removing a torture scene, she moved to the United States where she lived for ten years.
There she published in 1982 her short fiction book Change of Guard (Cambio de armas) and in 1983 The Lizard's Tail (Cola de lagartija), a novel about José López Rega, Minister of Social Welfare during Isabel Perón's presidency that was supposed to be originally titled as Red Ant Sorcerer, Lord of Tacurú and Her Sister Estrella (El Brujo Hormiga Roja, Señor del Tacurú y su Hermana Estrella).
[7][8] Luisa Valenzuela was a Resident Writer at the Center for Interamerican Relations at New York and Columbia University, where she taught writing workshops and seminars for ten years.