Wright hit a century on debut for Sussex, and has won the Denis Compton medal on three separate occasions during his domestic career.

[3][4] In April 2008, Wright played for the Marylebone Cricket Club (MCC) at the opening match of the 2008 county season.

With the Lions struggling, Wright hit 120 off 131 deliveries to bring them to 280 all out, giving rise to speculation about his place in the national team.

On 3 September it was announced that he would also join the England ODI squad as a replacement for the injured Ravi Bopara and Andrew Flintoff for the final two matches against India.

[7] On 5 September 2007 Wright made his One Day International debut against India at The Oval, London; hitting a half century in a 106 run 6th wicket stand with Middlesex batsmen Owais Shah.

Wright was selected for the 2007 Twenty20 World Cup in South Africa, and played his first match on 13 September against Zimbabwe, where he was out caught behind on this first ball.

In the autumn of 2009, he played against Australia, in a 6–1 loss, and in a surprisingly successful run at the ICC Champions Trophy, which was held in South Africa, where England beat the hosts and Sri Lanka before being thrashed by 9 wickets against Australia in the semi-finals (in which Wright scored 49, putting on a century partnership with Tim Bresnan).

On 9 January, Wright smashed 117 from 60 deliveries including nine sixes and eight fours against the Hobart Hurricanes at Blundstone Arena.

In the inaugural season of the Pakistan Super League in February 2016, Luke Wright played for Quetta Gladiators.

[19] In July 2019, he was selected to play for the Belfast Titans in the inaugural edition of the Euro T20 Slam cricket tournament.