Obliged to quit his country on account of his religion, he sought refuge in England about 1667, settled there, and rapidly became known as an acute and learned ecclesiastic.
In November 1670 he received the vicarage of Upton-cum-Chalvey, Buckinghamshire, having a short time before been elected divinity reader in St George's Chapel, Windsor Castle.
A year later we find him acting as chaplain to the infamous Judge Jeffreys, an office which he continued to hold till the revolution brought his patron's career to a close.
Beaulieu is chiefly known as the author of a remarkably eloquent and original manual of devotion, entitled "Claustrum Animæ, the Reformed Monastery, or the Love of Jesus", two parts, duodecimo, London, 1677–76, which reached a fourth edition in 1699.
The late Dr. George Oliver, of Exeter, possessed some curious correspondence of Luke de Beaulieu with a certain Franciscan friar, in reference to devotional manuals and books of meditation, which is said to indicate "the yet abiding influence of the Laudian revival up to that period".